Bifidum-Bacterine in the Treatment of Disturbances in the Microecological System of Large Intestine in Premature Infants

The period of adaptation to the extrauterine life is commonly complicated by disorders in the microecological system of the large intestine (MSLI) that diminish the physiological resistance of the premature infants. A comparison of Lactulose syrop (LS; Inalko, Italy) and lyophilized Bifidumbacterine (LB; Russia, 1 dose is 108 B. bifidum 1) effects on 75 premature infants at the gestational age 32.7 ± 0.2 weeks with the disturbances in MSLI was made. The Group 1 of 35 neonates received everyday 1.0 ml of LS/kg. The Group 2 of 40 infants received 2.5 doses of LB/3 times a day. The course of the treatment lasted for 14 days. All the babies were fed with native breast milk. The study of the infants included a general clinical examination; bacteriological examination of the feces; the study of the coprogramm, immunoglobulin A, G, M in coprofiltrates, and fecal pH / p < 0.05 was considered to be significant. After the treatment dyspeptic disorders disappeared in 90% and intestinal microflora normalized in 85% of neonates of Group 1. Normalization of above mentioned disorders after LB treatment was observed respectively only in 56% and 25% of neonates of Group 2. LS treatment led also to coprogramm normalization as well as to the significant decrease in immunoglobulin A content in coprofiltrates and fecal pH values. Thus utilization of LS in the treatment of the premature infants with disturbances in MSLI was more effective than that of LB.